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In an effort to save a crashing Richard from a deadly virus, Amy gets infected with it. Michael and the team work tirelessly to help her and the other patients, but their experimental treatments fail, and Amy becomes critically ill.
A mysterious, fast-acting and extremely deadly virus triggers an emergency lockdown on the 6th floor of Westside Hospital.
On Michael's first day as Chief of Internal Medicine, Joan arrives at the hospital as a patient in dire straits. Amy, determined to save her, clashes repeatedly with Richard over Joan's treatment plan. Meanwhile, Gina makes a nearly impossible medical decision for a young patient and Liz fights for her allegations against Richard to be taken seriously.
On her last day at Westside, Joan chooses an unlikely successor, crowns a Chief Resident and imparts some final wisdom to the next generation. Gina steps in to help TJ's patient, a foster child suffering from rheumatoid arthritis. Amy and Jake’s tension intensifies while treating a pregnant teen caught between her divorced parents.
When Amy and Michael take Katie on a road trip to her college orientation, they pass a familiar campsite and decide to stop and hike the trail. The journey quickly becomes harrowing when they discover an injured man whose life hangs in the balance. Stranded in the middle of nowhere, with no cell service, it's up to the three of them to somehow save him.
After a tragic accident, one of Joan’s oldest friends is rushed to Minneapolis to be treated by her, forcing Amy to confront her about her illness. Richard and TJ find themselves at odds when they treat a tech bro who thrives on pushing boundaries. Michael tries to pick up the pieces in the wake of his fractured marriage.
Met with hostility upon his return, Richard looks to redeem himself while treating an overworked food delivery worker. Sonya and TJ enlist Jake’s help with the delicate Joan situation. Amy and TJ take on the case of a well-known medical malpractice lawyer, leading to unexpected complications.
While navigating the fallout from Katie’s secret, Amy treats a critically ill patient with a dark one of her own. As Gina and Jake evaluate a world-class poker player, searching for the source of what may be a mental disorder, Jake is forced to hide the truth from Amy about Rachel’s health scare. Sonya and TJ investigate their theory behind Joan’s frequent absences. And Richard returns with a trick up his sleeve.
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